publications

  1. Zhu T*. Mirror of the unknown: should research on mirror-image molecular biology be stopped? Nature, 645:588-591, (2025). (Highlighted by Nature) [PDF]
  2. Zhang G, Zhu T*. Mirror-image trypsin digestion and sequencing of D-proteins. Nature Chemistry, 16:592-598, (2024). (Highlighted by Chemistry World) [PDF]
  3. Xu Y, Zhu T*. Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs. Science, 378:405-412, (2022). (Highlighted by Science [PDF], Nature [PDF], Singularity Hub, and C&EN) [PDF]
  4. Chen J, Chen M, Zhu T*. Directed evolution and selection of biostable L-DNA aptamers with a mirror-image DNA polymerase. Nature Biotechnology, 40:1601-1609, (2022). [PDF]
  5. Fan C#, Deng Q#, Zhu T*. Bioorthogonal information storage in L-DNA with a high-fidelity mirror-image Pfu DNA polymerase. Nature Biotechnology, 39:1548-1555, (2021). (Highlighted by Science, Phys.org, and C&EN) [PDF]
  6. Chen J, Chen M, Zhu T*. Translating protein enzymes without aminoacyl-tRNA synthetases. Chem, 7:786-798, (2021). [PDF]
  7. Ling JJ#, Fan C#, Qin H, Wang M, Chen J, Wittung-Stafshede P, Zhu T*. Mirror-image 5S ribonucleoprotein complexes. Angewandte Chemie International Edition, 59:3724-3731, (2020). [PDF]
  8. Qin N#,*, Liang P#, Wu C#, Wang G, Xu Q, Xiong X, Wang T, Zolfo M, Segata N, Qin H, Knight R, Gilbert JA*, Zhu T*. Longitudinal survey of microbiome associated with particulate matter in a megacity. Genome Biology, 21:55, (2020). [PDF]
  9. Wang M#, Jiang W#, Liu X#, Wang J#, Zhang B, Fan C, Liu L, Pena-Alcantara G, Ling JJ, Chen J, Zhu T*. Mirror-image gene transcription and reverse transcription. Chem, 5:848-857, (2019). [PDF]
  10. Liu X, Zhu T*. Sequencing mirror-image DNA chemically. Cell Chemical Biology, 25:1151-1156, (2018). [PDF]
  11. Wang G#, Du M#, Wang J*, Zhu T*. Genetic variation may confound analysis of CRISPR-Cas9 off-target mutations. Cell Discovery, 4:18, (2018). [PDF]
  12. Kayani MU#, Doyle SM#, Sangwan N, Wang G, Gilbert JA*, Christner BC*, Zhu T*. Metagenomic analysis of basal ice from an Alaskan glacier. Microbiome, 6:123, (2018). [PDF]
  13. Jiang W#, Zhang B#, Fan C#, Wang M#, Wang J, Deng Q, Liu X, Chen J, Zheng J, Liu L*, Zhu T*. Mirror-image polymerase chain reaction. Cell Discovery, 3:17037, (2017). [PDF]
  14. Xu W#, Jiang W#, Wang J#, Yu L#, Chen J, Liu X, Liu L*, Zhu T*. Total chemical synthesis of a thermostable enzyme capable of polymerase chain reaction. Cell Discovery, 3:17008, (2017). [PDF]
  15. Wang Z#, Xu W#, Liu L*, Zhu T*. A synthetic molecular system capable of mirror-image genetic replication and transcription. Nature Chemistry, 8:698-704, (2016). (Highlighted by Nature [PDF], Scientific American, C&EN, and F1000Prime) [PDF]
  16. Jiang W*, Zhu T*. Targeted isolation and cloning of 100-kb microbial genomic sequences by Cas9-assisted targeting of chromosome segments. Nature Protocols, 11:960-975, (2016). [PDF]
  17. Jiang W, Zhao X, Gabrieli T, Lou C*, Ebenstein Y*, Zhu T*. Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters. Nature Communications, 6:8101, (2015). [PDF]
  18. Zheng Y#, Kayani MU#, Zhu T*. Rapid identification of multi-strain HBV infection in patient by high-throughput DNA sequencing. Quantitative Biology, 3:103-106, (2015). [PDF]
  19. Jiang W, Liang P, Wang B, Fang J, Lang J, Tian G, Jiang J, Zhu T*. Optimized DNA extraction and metagenomic sequencing of airborne microbial communities. Nature Protocols, 10:768-779, (2015). [PDF]
  20. Cao C, Jiang W#, Wang B#, Fang J, Lang J, Tian G*, Jiang J*, Zhu T*. Inhalable microorganisms in Beijing's PM2.5 and PM10 pollutants during a severe smog event. Environmental Science & Technology, 48:1499-1507, (2014). (Web of Science 'Highly Cited Paper': top 1% of the field; Highlighted by Nature [PDF], Scientific American, Popular Science, The Scientist, Los Angeles Times, and Business Insider) [PDF]

*Corresponding author(s)
#Equal contributions